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Home Science, technology and technology news The development of immunity after infection with coronavirus has been proven

The development of immunity after infection with coronavirus has been proven

by alex

The development of immunity after infection with coronavirus has been proven

Scientists at the University of Oxford in the United States have proven that infection with the SARS-CoV-2 coronavirus in most cases causes the development of a stable T-cell immune response. The results of scientific work are published in the journal Nature Immunology.

While it is already known that a B-cell antibody response develops after infection with COVID-19, it was unclear if the pathogen could cause the immune system to produce virus-specific T cells that promote recovery and provide protection against subsequent infections.

Researchers analyzed blood samples from 14 severe COVID-19 patients and 28 people with mild symptoms to identify proteins containing epitopes – fragments that T cells specifically bind to. It turned out that people with mild COVID-19 had a different pattern of T-cell response compared to people with more severe infection.

Although a low-quality T-cell response may contribute to the persistence of the SARS-CoV-2 virus and a high risk of death from COVID-19, recovered patients, regardless of the severity of the disease, still retained T-cell memory for two months after infection.

The researchers also found that the coronavirus S-protein is often recognized by the T cells of recovered patients, which confirms the effectiveness of the current vaccine development approaches. In addition, other parts of the virus, including its membrane and nucleoproteins, also elicit a strong T-cell immune response, which increases the number of potential vaccine targets.

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