Scientists at the University of Texas at San Antonio described the method by which the coronavirus SARS-CoV-2 is able to freely enter the cells without causing activation of protective systems. To do this, he disguises his own molecules under cellular connection. About the cunning mechanism of infection reported in the article Nature Communications.
It turned out, one of the key roles in infected cells plays a viral enzyme nsp16. It modifies the cap-structure at the end of messenger RNA that are used to transfer the genetic information contained in DNA to the ribosome, which produces protein synthesis. Cap performs a variety of functions, including regulation of RNA transport between the nucleus and the ribosomes. Due to the modification of the cap of viral RNA, the cell cannot recognize foreign molecules and considers it part of themselves.
Transcript of the three-dimensional structure of nsp16 will allow you to develop effective antiviral drugs for the treatment of COVID-19, which will prevent modification of caps.
Previously, scientists have found that cellular protein neuropilin-1 (NRP1) provides insight coronavirus in the brain of the media. Coronavirus does not multiply in the brain cells, but it can cause their death.
