Moscow. The 20th of October. INTERFAX.RU – Scientists from the St. Petersburg State University, the St. Petersburg Federal Research Center of the Russian Academy of Sciences and the Scientific Research Center for Environmental Safety of the Russian Academy of Sciences have developed a new organic compound, the biological activity of which increases under the influence of a laser. This was reported by the press service of the university on Wednesday.
“The problem of the controlled effect of drugs on the human body is being actively investigated in photopharmacology, the field of pharmaceuticals that studies substances that change their activity under the influence of light. Chemists of St. when the substance reaches the area of inflammation. ” – the message says.
The created phosphonate will allow a more accurate and safer effect on the cells of the body. The resulting substance can find its application in ophthalmology, the treatment of neurodegenerative diseases (for example, Alzheimer's disease) and other fields of medicine, since the synthesized phosphonate is an inhibitor of cholinesterase, an important enzyme of the nervous and other systems of the human body.
Earlier, a research group of St. Petersburg scientists developed a substance, the biological activity of which decreases under the influence of light. The new phosphonate has the opposite effect. The author of the study, Professor of the Department of Laser Chemistry and Laser Materials Science of St. Petersburg State University, Doctor of Chemistry Alina Manshina notes that in the future these compounds may be used together, controlling both “on” and “off”, but this requires additional research.
“Potentially, this can be used to solve the problems of personalized medicine, which takes into account the characteristics of each person and selects the optimal doses and duration of exposure to the substance,” the press service quotes Manshin.
An article with the results of the study was published in the chemical scientific journal New Journal of Chemistry, published by the Royal Society of Chemistry.
