An international team of researchers has come to the conclusion that the level of expression of the so-called flower protein can reasonably accurately predict the outcome of a coronavirus infection – be it death or hospitalization – in a person. A corresponding article on the way scientists have found a way to predict the course of COVID-19, published in the journal EMBO Molecular Medicine.
The low fitness status of a cell indicates that it is not well developed – either due to its aging, or due to metabolic disorders, and so on. The scientists found that fitness status is expressed in FWE proteins. They are located on the cell surface and are expressed in two forms – one says that the cell feels good, and the “possessors” of the other are destroyed by the surrounding cells.
Scientists from the UK, Germany, Denmark, Portugal and the United States conducted a postmortem examination of coronavirus-infected lung tissues of patients who died from COVID-19. It turned out that in patients with acute lung injury, Fwe-Lose was extremely strongly expressed in the lower airways and was localized in areas of cell necrosis.
Then the experts conducted an observational study of 283 people in order to determine whether the level of expression of the FWE protein can predict hospitalization or death with COVID-19. “The method makes it possible to determine who needs hospitalization with an accuracy rate of 87.8 percent. The accuracy of predicting patients who will not develop severe COVID-19 was 93.9 percent, ”says one of the study authors, assistant professor at the University of Copenhagen Ken Jae Won (Kyoung Jae Won). The accuracy of predicting deaths can be up to 100 percent. The researchers emphasize that the level of expression of the FWE protein can better predict the outcome of the disease than traditional inflammatory biomarkers.
