Monash University Scientists Link Exercise To Type 2 Diabetes Prevention
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Scientists at Monash University in Australia have discovered an enzyme that plays a key role in improving health through exercise. The discovery could become the basis for drugs that promote enzyme activity and protect against the effects of aging and age-related diseases, such as type 2 diabetes. This is reported in an article published in the journal Science Advances.
One of the main causes of type 2 diabetes as an age-related disease is the development of insulin resistance or the body's inability to respond to insulin, which is often associated with decreased physical activity. The researchers found that physical activity actually increases insulin sensitivity and, in turn, promotes healthy metabolism and disease prevention.
The reduction in the production of reactive oxygen species (ROS) in skeletal muscle during aging contributes to the development of insulin resistance. ROS provoke adaptive responses that are integral to the health benefits of exercise. The production of reactive oxygen species is enhanced with the participation of the NOX-4 enzyme. It has been shown that the content of NOX-4 in skeletal muscle decreases with age, and this correlates with an increase in insulin resistance.
Scientists say NOX-4 enhancing agents are found naturally in cruciferous vegetables such as broccoli and cauliflower, but the amount required is significantly higher than what many people are willing to consume.